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Essential Fatty Acids: Biochemistry, Physiology and Pathology

Schedule Your Free Consultation Today About the Author Author:** Blueline Wellness Group Medical Team Medical Reviewer:** Jose Vazquez, LVN Published:** December 17, 2025 Last Updated:** December 17, 2025 Fact-Checked:** Yes Patient-Reviewed:** Yes Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice

In colon cancer cells (HT-29 and SW480 cells), genetic knockout of IGF-1R or the use of the IGF-1R inhibitor NVP-ADW742 enhanced the killing effect of radiation on cancer cells, confirming that depletion of IGF-1R improves radiosensitivity to colon cancer therapy (145,146)

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doi: 10.1016/j.bbmt.2010.01.001