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Local anesthetic solutions containing antimicrobial preservatives (eg, methylparaben) should not be used for epidural or spinal anesthesia because the safety of these agents has not been established with regard to intrathecal injection, either intentional or accidental

33 , 18611871, doi: 10.1161/ATVBAHA.112.301068 (2013)

(PubMed) Taggart DP, Jenkins M, Hooper J, et al

Medication remains effective unless storage conditions are poor or it has expired rather than due to the body building tolerance

TAM demonstrated clinically significant effects of reducing breast cancer recurrence rate by 40%50% and could reduce the mortality and temporary remission rate after treatment and may reduce mortality and increase remission rate (Karn et al., 2010)