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in Methods Enzymol

doi: 10.3390/cancers12041045 27 Rubbert-RothAEnejosaJPanganALHaraouiBRischmuellerMKhanNet al

Nrf2 knockdown prevents NFT-dependent increase in cellular glutathione levels To examine the correlation between Nrf2 activation and the increase in glutathione levels after NFT treatment, Nrf2 protein levels were experimentally lowered by siRNA-mediated knockdown, which was confirmed by Western blotting (Fig

263 In castration-resistant prostate cancer, the UPS supports androgen receptor (AR) function by facilitating its nuclear localization and stabilizing mutated AR proteins, enabling tumor cells to survive and proliferate under low androgen levels