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It is supposed the homozygous genotype with the variant allele is rarer and less favourable for the subject (apart from specific exceptions) with respect to the homozygous wild type, bearing the commonest allele, while the heterozygous genotype is represented as an intermediate condition

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THE PROBLEM Your B12 Supplement Might Be Working Against You If you're taking a standard B12 supplement and still feel tired, foggy, or have nerve pain, there's a reason