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However, the biological effectsincreased synaptic density, elevated expression of synaptogenic proteins like synaptophysin and PSD-95, and enhanced dendritic spine formationpersist for 7-14 days after administration

It should be noted, due to the gaseous and short-lived nature of NO and ONOO - , the likelihood of delayed and accumulated toxicity after the completion of treatment is minimal [58, 59]

A recent systematic review of 39 RCTs using supplemental micronutrients or phytochemicals found that the trials utilized 121 different cognitive tasks, thereby making it difficult for comparison among studies and for overall data interpretation (131)

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