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On day 10 after inoculation, tumor-bearing mice were treated with vehicle (saline), APR-017(100 mg/kg per day, ip., for 10 days), IC261(0.6 mg/kg per day, ip., for 10 days), or APR-017 + IC261, and tumor growth was monitored via in vivo imaging (IVIS)

Methodology, XW and RW

By its role in altering the composition of the gut microbiome, IF decreases intestinal permeability and initiates WAT browning

Depletion of GSH levels necessary for adequate protection to less than 20-30% has been suggested as an explanation of hepatotoxicity of higher doses of compounds such as paracetamol or bromobenzene [13]

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