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Interestingly, DNA sequencing of non-malignant lung tissue revealed EGFR and KRAS mutations in 18% (54 out of 295) and 53% (43 out of 81) of samples, respectively, leading to the hypothesis that these mutations accumulate as part of the ageing process and that PM 2.5 promotes subsequent tumour formation in the at-risk epithelium harbouring these driver mutations 279

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