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Ovarian stimulation may exacerbate this by expanding the implantation window and increasing estrogen levels, potentially lowering pregnancy rates

140,141,142 Traditionally, lactate was considered to be a minor byproduct of glucose utilization in anaerobic environments, but studies now indicate that lactate is an irreplaceable and primary fuel for energy and is crucial for the TCA cycle

Synthetic biology techniques, such as gene editing and genetic engineering, can greatly improve biological activity and deliver MOTS-c directly to the acting site, thus further expanding the therapeutic application of MOTS-c

However, even slight variations, such as alterations in the dimensions of lipoprotein particles and an elevation in LDL II and IV subtypes, could potentially contribute to an increased susceptibility to macrovascular disease in people [107]

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