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1980s : Advances in immunology lead to a better understanding of the autoimmune nature of Graves disease, spearheaded by researchers at institutions like the National Institutes of Health (NIH)

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Rooyackers O Article: JOURNAL OF LIPID RESEARCH

Some protocols recommend gradual titration up to 20 to 45 mg per day if no significant side effects appear

It is common to combine corticosteroids with a local anesthetic, which can provide some initial numbing and relief of the affected area since the anti-inflammatory effects may take days to set in