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Self-assembling peptide hydrogels: design, mechanisms, characterization, and biomedical applications

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Although no hypersensitivity to DNA-damaging agents has yet been reported in SCA3 patients, a dramatic increase in DNA damage in mutant ATXN3 cells, SCA3 mouse brains, and brain sections from SCA3 patients further supported the impact of ATXN3 aggregation and toxicity in DNA repair [103, 104]

-Random assignment of participants to treatment/comparison groups

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