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A Phase IIb trial of mRNA-4157 in combination with pembrolizumab for patients with resected high-risk melanoma showed that this combination therapy prolonged recurrence-free survival compared with pembrolizumab monotherapy and had a manageable safety profile

It is a synthetic tetrapeptide that is studied in relation to compounds derived from the pineal gland

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Its prevalence increases significantly with age, rendering it the principal cause of blindness globally, responsible for approximately 48% of blindness cases [35]