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48 Together with the diversity of ubiquitin linkage types, this architectural variability gives the UPS its extraordinary precision, enabling tight regulation of proteostasis and preventing the accumulation of toxic proteins under physiological and pathological stress

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The studies reported thus far have used exhaustion models of endurance-based exercise leaving the area of resistance exercise, specifically damaging eccentric exercise a major area of research to be conducted

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In order to test this hypothesis, experiments were carried out in the presence of tetrodotoxin (TTX, 500 nM) in order to block synaptic transmission