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Activin A, a member of the TGF- superfamily was thought to be involved in the pathogenesis of UF by increasing the ECM components, such as versican, fibronectin, and collagen 1A1, at least in part through activating the Smad-2/3 and p38-MAPK signaling pathway (Islam et al., 2014

Specifically, high intakes of calories, carbohydrates, saturated fats, and sugar coupled with low intake of fiber have been linked to increased risk, while consumption of polyunsaturated fats, fiber, fish, fruits and vegetables, and nuts have been associated with lower risk (Pak 2016)

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Delta Sleep-Inducing Peptide (DSIP): A Tool for Investigating the Sleep Onset Mechanism