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Rapoport JL, Giedd J, Kumra S, Jacobsen L, Smith A, Lee P et al (1997)

The performance of the mannitol excretion test in other disease conditions and treatments will need to be evaluated and compared against the multitude of studies using a combined assessment of lactulose and mannitol excretion (13)

pg 134-142

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The thymus, the organ responsible for educating immune T-cells, shrinks so dramatically with age that by the time most people reach their forties, it has been largely replaced by fat tissue, leaving the immune system relying on an aging, diminishing repertoire of cells [2]