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Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

Intravenous and intramuscular routes deliver chelators into the circulation more directly, which is useful for systemic iron removal but still only offers limited brain uptake in most chronic conditions

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Our approach to identify pathways directly affected by Gsta4 over-expression and sequent reduction of mitochondrial 4-HNE load consisted in overlapping two independent databases of 4-HNE modified proteins, together with assessing their transcription in the OL lineage