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Statistical analysis All statistical analysis was completed using either R or GraphPad Prism (v.10.6.1)

Emerging evidence reported the role of glutamine mediating reductive carboxylation for lipid biosynthesis and also for redox homeostasis in cancer with dysfunctional mitochondria or under hypoxia [34,41-43]

Pharmacokinetic analysis revealed it to be orally active with significantly increased metabolic stability, exhibiting a plasma half-life of 335.5 minutes, allowing for prolonged systemic availability [2]

Stable isotope tracing experiments mimicked the results observed in IDH1/ cells

It has been shown that the crizotinib induces alterations in the secretome of the melanoma cells contributing to the emergence and expansion of the resistant subpopulations [86]