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When methylation is impaired, it can contribute to major chronic conditions, including cardiovascular diseases, infertility, unexplained miscarriages, problems during pregnancy, mood disorders, free radical damage (premature ageing), diabetes, neural tube defects, neurological conditions, chronic fatigue syndrome

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If HNC is diagnosed in the early developmental stages (I or II), a benign course of the pathology can reasonably be assumed

Conflict of interest The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article