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Efficacy and safety of pregabalin for treating neuropathic pain associated with diabetic peripheral neuropathy: a 14 week, randomized, double-blind, placebo-controlled trial

A visual summary of these pathways is illustrated in Figure 3

From a neurobiological perspective, in this stage of the addiction cycle, alcohol consumption is a goal-directed behavior, initiated and executed by brain areas within the executive control network, with its rewarding effects processed by appetitive drive regions (Kyzar and Pandey, 2015)

(Abbreviations used in this paper along with their complete names are listed in Glossary.) Figure 1 An important theme in interpreting vitamin B 12 deficiency is the remethylation block hypothesis: Vitamin B 12 deficiency results in hyperhomocysteinemia because Hcy remethylation is blocked (Selhub et al., 2007)

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