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The latter was mostly mediated by weight loss rather than glucose control 106

Freeman, PhD, explains that your mental health history factors into your risk: Women with a history of depression are nearly five times more likely to have a diagnosis of major depression in the menopausal transition, whereas women with no history of depression are two to four times more likely to report depressed mood compared with premenopausal women. Estrogen helps to support feel good brain chemicals, such as serotonin and norepinephrine, responsible for mood stabilization, alertness and energy

Second, we have the diluent

Regular follow-up appointments allow for dose optimization, adverse effect management, and assessment of treatment efficacy across multiple health parameters

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