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Changes in weight and fat distribution are common during menopause, which can also add stress to joints

10.1016/j.neuropharm.2016.05.009 268

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Trajectories of mood and cognition in late-life depression Treatment outcomes in LLD are highly variable, with first-line antidepressants (selective serotonin reuptake inhibitors [SSRI] or selective noradrenergic reuptake inhibitors [SNRI]) effective in only about half of patients [21, 22]

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