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Here are some conditions where you may need B12 shots: You have vitamin B12 deficiency or pernicious anemia

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Gradual titration is essential: Starting low (around 0.25 mg weekly) and stepping up slowly markedly lowers the odds of early gastrointestinal effects [4]

Some doctors may even prescribe B12 injections to prevent deficiencies before they start (especially if your bloodwork's numbers are on the low side).If you suffer from anemia or a B12 deficiency, you may need B12 as a treatment