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Their results indicated that elevated urinary mercury levels were significantly associated with reduced PFT values, increased levels of oxidative stress biomarkers such as 8-hydroxy-2-deoxyguanosine (8-OHdG) and 8-iso-prostaglandin F2 (8-iso-PGF2), and decreased expression of the antioxidant enzyme NAD(P)H quinone oxidoreductase 1 (NQO1) in lung tissue [50]

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These results showed that FBI-1 could enhance the expression of GPX4 by suppressing that of miRNA-324-3p in PC-3 cells