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While these can reduce inflammation, they often bring difficult side effects: Weight gain, bloating, and bone loss Increased infection risk Fatigue and mood changes High long-term costs Because these drugs suppress the immune system instead of balancing it, flare-ups frequently return once treatment stops

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Women may experience changes in hormone levels and metabolic needs during pregnancy, such as an increase demand for THs to meet the needs of fetal growth and brain development

Funding This work was funded by the Natural Sciences and Engineering Research Council of Canada (NSERC, Discovery grant nos