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8, 9, 10, 11 Oxidative stress occurs as the result of an accumulation of free radicals generated by normal metabolism and various environmental exposures to elicit cellular dysfunction

I've experienced this myself and the data looked to me pretty darn solid

alternative-therapies.com PubMed Selective good angiogenesis, blocks bad angiogenesis (evidence: context dependent rodent preclinical modulation, unvalidated in humans)