Via high-butyrate diet intervention and adoptive transfer experiments, it confirmed that a high-butyrate diet can induce the differentiation of follicular Tregs through HDAC inhibition, suppress the production of type II collagen (CII)-specific autoantibodies, and reduce joint swelling and bone erosion
Additionally, the reliability of these findings is compromised by the small number of participants and the short duration of the treatments, which lasted only 4 and 8 weeks
Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)
Peptides therapy aims to replace whatever is lost
It's important to note that while vitamin B12 injections are effective in quickly raising B12 levels, dietary changes and oral supplements are often recommended for long-term maintenance
