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ScGrx7 is particularly suited for unbiased kinetic and mechanistic studies because of its high activity, the absence of ironsulfur clusters in enzyme preparations and the lack of additional cysteine residues 11 (glutaredoxins with two or more cysteine residues have complex kinetics because of alternative redox states and reactions 10,12,14,17,30,31,32,33 )

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We therefore examined if neurodegeneration in the GCLC-KO mouse is associated with neuroinflammation

Oxidative stress is associated with the auto-phosphorylation of ATM at S1981 51 , but this was not detected by Western blot analysis in the current study

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