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NRF2 provides a protective effect in melanocytes in response to both UV irradiation and oxidative stress 30,31 , through transcriptional upregulation of the antioxidant response element (ARE) genes including Superoxide dismutase-1 (SOD-1), Glutathione peroxidase-1 (GP-1), Glutathione reductase-1 (GR-1), Catalase and Heme oxygenase-1 (HO-1) 38,39,40

Effectiveness of glutathione (gsh) 2%, tocopheryl acetate 1%, and magnesium ascorbyl phosphate 3% combination cream compared with hydroquinone 4% cream as a skin lightening agent: a randomised study