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Contraindications Sulfamethoxazole and trimethoprim is contraindicated in the following situations: known hypersensitivity to trimethoprim or sulfonamides history of drug-induced immune thrombocytopenia with use of trimethoprim and/or sulfonamides documented megaloblastic anemia due to folate deficiency pediatric patients less than 2 months of age marked hepatic damage severe renal insufficiency when renal function status cannot be monitored concomitant administration with dofetilide (see PRECAUTIONS)

The possibility that oxidized forms of ascorbate play signalling roles cannot be discounted (Xu et al

As seen in Figure 5, DEM administration severely depleted mucosal GSH by 1 hour to levels similar to those of TNBS+ethanol-treated rats