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Individuals with Pernicious Anemia: This condition affects the ability to absorb B12, often requiring lifelong supplementation

Methods: Eligible participants include stroke patients with mild physical impairments (mRS 0-2) discharged home with low balance confidence (ABC 65) was associated with higher mortality than those with good diabetic control (52% vs 10%)

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doi:10.1038/s41392-022-00904-4 US Food and Drug Administration

While BPC-157 does not develop traditional tolerance, cycling remains common practice for several reasons including receptor sensitivity maintenance, cost management, and conservative approach given limited long-term human data