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However, this study employed two-dimensional gel electrophoresis (2DE), a technique with known limitations, including low sensitivity, restricted dynamic range, and gel-to-gel variability

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In OA, This iron overload is closely related to disease progression, as it not only directly induces chondrocyte apoptosis but also accelerates cartilage degradation by upregulating matrix-degrading enzyme expression (Jing et al., 2021a)

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