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(Reproduced with permission from Wessells H et al

Their deficiency is among the most common and impactful nutritional shortfalls affecting quality of life tingling, numbness, fatigue, and cognitive decline are all correctable symptoms of deficiency

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Secondary outcomes include assessments of specific symptoms (headache, quality of life, mood, anxiety, fatigue, dizziness, sleep parameters, daytime sleepiness) in addition to blood biomarkers and magnetic resonance imaging and spectroscopy data for quantification of brain metabolites including -aminobutyric acid (GABA), glutathione, glutamate and N-acetyl aspartate (NAA) all measured at 6 and 12-weeks of intervention

To this end, the shotgun results agreed with the in silico analysis (CARD and KEGG databases) that the enrichment of specific ABR genes may be linked to species within the Enterobacteriaceae family, namely E