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10.1056/nejmra1708111 N Engl J Med

(2) temperature: leaf quality as low temperatures increase leaf thickness, but reduce leaf size and softness 2

The standard taper schedule for users on daily protocols: reduce to every-other-day dosing for one week, then drop to twice weekly for another week, then cease entirely

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Rather, these signals reflect context-dependent processes that can drive both beneficial and detrimental outcomes, ranging from tissue repair and neuroprotection to inflammation and neurodegeneration