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As expected, in ligature induced experimental periodontitis, a considerable increase in vascular permeability in the gingival tissue was detected

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Vernet P, Rigaudiere N, Ghyselinck N, Dufaure JP, Drevet JR

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The addition of a negative charge to the normally neutral hydroxyl moiety of tyrosine can profoundly alter protein shape and function through electrostatic interactions, and nitration is often quite spatially specific due to the high reactivity of superoxide and peroxynitrite

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