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found that luteolin reduces uterine weight, exhibits pro-apoptotic and anti-proliferative effects, improves the proliferation of fibroid cells in a rat uterine fibroid model induced by diethylstilbestrol and progesterone, significantly lowers -SMA protein expression, and inhibits TGF-1 and PI3K-mediated signaling pathways by enhancing PTEN expression, ultimately achieving an anti-fibroid growth effect [129]

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This indicates that FOXO4 facilitates expression of the p53-target p21 in senescent Leydig cells