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This is so because, due to a deficiency of iodine, the increased production of TSH stimulates compensatory growth of the thyroid follicular cells for the deficiency of these hormones, resulting in goiter (Kolesnik et al

Delaying medical care for serious complications can lead to worse outcomes

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Bacterial urease further hydrolyzes these diffused urea to ammonia and ammonium hydroxide, thereby causing an increase in the pH of the gut lumen and altering the gut microbiota balance (Kang, 1993