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Introduction Have you noticed excessive hair shedding, thinning patches, or brittle strands that break easily
We speculate that downregulation of HIF-1 via the mTOR1 pathway or alleviation of the hypoxic microenvironment may attenuate the Warburg effect, impede T cell differentiation, inhibit glycolytic metabolism, and modulate inflammatory and immune responses in AID patients such as SLE
Methods A literature search was conducted in the MEDLINE (via PubMed) and Web of Science databases from the inception up February 2020
Voorhees, J
doi: 10.3389/fnut.2025.1754492 Received 26 November 2025 Revised 20 December 2025 Accepted 24 December 2025 Published 21 January 2026 Volume 12 - 2025 Edited by Javier Diaz-Castro, University of Granada, Spain Reviewed by Mahsa Rezazadegan, Isfahan University of Medical Sciences, Iran Soroush Taherkhani, Iran University of Medical Sciences, Iran Updates Copyright 2026 Poon, Li, Schweitzer and Akefe
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