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You may notice acne developing within a few days or weeks of starting vitamin B12 supplements

doi: 10.1046/j.1600-0749.2003.00093.x [DOI] [PubMed] [Google Scholar] 33.Yin Y., Li W., Son Y.O., Sun L., Lu J., Kim D., Wang X., Yao H., Wang L., Pratheeshkumar P., Hitron A.J., Luo J., Gao N., Shi X., Zhang Z.2013

For acute injuries with significant pain and swelling, some practitioners and experienced users suggest a higher loading approach during the first 3-5 days: 0.5 mg twice daily (1 mg total) before reducing to maintenance dosing

doi:10.1021/jf402866q Rollini M, Manzoni M (2006) Influence of different fermentation parameters on glutathione volumetric productivity by Saccharomyces cerevisiae