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The compound's copper delivery function is also important, as copper is an essential cofactor for lysyl oxidase (collagen crosslinking), superoxide dismutase (antioxidant defense), and cytochrome c oxidase (mitochondrial energy production)

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The RGDfK peptide-camptothecin conjugate linked by a Lys splitter enhanced cytotoxicity to melanoma and non-small cell lung cancer cells 80