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We will still be adequately powered to make comparisons between these scenarios, and by shifting to 2 scenarios while retaining our total target enrollment, we will have higher numbers of individuals in these groups than planned which could allow us to evaluate additional moderating factors by subgroups, such as sex or age

But significant differences in nicotine strength, moisture level, and filler technology creates a diverse array of performance envelopes

Lindahl-Jacobsen R, Oeppen J, Rizzi S, Mller S, Zarulli V, Christensen K, Vaupel JW

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