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However, one study on the treatment of children with methylmalonic acidemia and homocystinuria found oral hydroxocobalamine at 1 mg daily to be ineffective in reducing levels of homocysteine

5) Other Medical Conditions Persistently high vitamin B12 has been observed in some cancers and in certain chronic inflammatory conditions

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The drug also has adverse side effects such as diarrhea and vomiting, "but because these medications are titrated, meaning that the dose is increased gradually, we find a rate at which we can cease that side effect," according to Aronne

It causes persistent feelings of sadness, hopelessness, and emptiness, as well as anger, frustration, irritability, and loss of interest and pleasure in activities