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Luteolin has been observed to inhibit the Janus kinase 2 (JAK2)/STAT3 signaling pathway in AD mouse model, along with reduced IL-17 expression and diminished Th17-mediated inflammatory responses (Tang et al., 2022)

(2013) 4:105/XML/NLM

It is caused by a selective loss of a small population of neurons in the lateral hypothalamus that synthesise hypocretin neuropeptides (Dauvilliers & Barateau, 2017)

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Neurogenic Differentiation and Epigenetic Gene Regulation A more recent and mechanistically distinct research domain for the AEDG sequence involves its effects on gene expression during neurogenesis