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The consequences are sinking levels of zinc, selenium, magnesium and glutathione, which can not be compensated by the food supply

Reiss Y, Droste J, Heil M, Tribulova S, Schmidt MH, Schaper W, Dumont DJ, Plate KH (2007) Angiopoietin-2 impairs revascularization after limb ischemia

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Above that threshold, additional methionine or choline doesn't compound the effect because the liver's methylation enzyme capacity is saturated

It is critically involved in a wide range of biological processes, including modulation of OS, maintenance of cellular homeostasis, immune regulation, DNA replication and damage repair, cell cycle progression, apoptosis, and aging (103)