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Vitamin B12 is naturally found in animal products such as dairy, shellfish, meat, fish and liver

When compounds are injected intramuscularly, they're rapidly taken up by these blood vessels, leading to faster peak concentrations compared to subcutaneous administration

Tirzepatide with niacinamide adds a B3 vitamin component that some researchers believe supports metabolic function during weight loss

(2014, PMID 23755725) reported effects on the nitric oxide system in rodent models, and Chang et al