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The phenomenon of darkening of the skin is generally known as melanin hyperpigmentation, and it is caused by the overproduction of melanin pigmentation by the melanocytes which are found on the skin

Hammi C, Yeung B

"An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP." Proc Natl Acad Sci U S A 105(26): 9093- 8 Wayman, G

Recent studies report altered expression of SOD isoforms, particularly in breast cancer, where elevated SOD levels support tumor survival under oxidative stress

Specific carotenoids like fucoxanthin and astaxanthin have shown promise in inducing apoptosis and reducing cell migration, highlighting their potential as adjuvants in melanoma therapy 187,192