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Eye cream trial (41 women, 12 weeks): A GHK-Cu eye cream for photodamaged periorbital skin outperformed both placebo and vitamin K cream

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In contrast, less severe mood disorders did not show this familial pattern, supporting the idea that BP-II is a distinct and genetically separate condition

However, few studies have examined the relationship of vitamin B 12 status, homocysteine concentrations, and the development of depression over time