Given the role of Metabolic pathway analyses between the LC and R group revealed also the alteration of 18 pathways, however, 15 out of these 18 pathways were similar to those observed between LC versus HCs ( Figure 4A )
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In contrast to PP1 and PP2A phosphatases, which form multimeric complexes in regulating their catalytic activities, PP5 operates as a monomeric enzyme with an intramolecular interaction that keeps it inactive 24,25
