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Either way, they're still addicts." Vaping devices are now making headlines across the world following an outbreak of severe lung disease in the US which could be associated with e-cigarette use

The Dopamine Reward System and Pleasure Response The brains reward system responds powerfully to nicotine through a complex cascade of neurochemical events centered on dopamine signaling

Am J Respir Crit Care Med 189:263273 Geraghty P, Wallace A, D'Armiento JM (2011) Induction of the unfolded protein response by cigarette smoke is primarily an activating transcription factor 4-C/EBP homologous protein mediated process