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In scientific literature, NNMT is recognized as an enzyme that methylates nicotinamide (a precursor of NAD+) using S-adenosylmethionine (SAM) as the methyl donor, converting it to 1-methylnicotinamide (MNA) and potentially affecting cellular NAD+ availability

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(5) Research has shown that by preserving nicotinamide from NNMT-mediated degradation, the compound may enhance NAD+ synthesis through the salvage pathway

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