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Located at key interfaces, including the BBB, meninges, and perivascular spaces, mast cells are uniquely positioned to detect environmental stressors and rapidly respond by releasing a potent cocktail of mediators such as histamine, tryptase, cytokines, and prostaglandins

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However, in scurvy, vitamin C is retained by the brain for neuronal function, and eventual death from the disease is more likely due to lack of vitamin C for collagen synthesis (44)

Any yellowing, browning, or other discoloration is a red flag

Int J Parasitology: Drugs Drug Resistance