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Continuous intrathecal recombinant human HGF injections exert functional recovery in non-human primate model of SCI (Aoki et al., 2019) and protect from neuronal death in ALS mice models (Ishigaki et al., 2007)

18 O incorporation into cyanidin (8) Flavan-3,3,4-triol ( 4 ) was first formed in a reaction with 100 mM MOPSO, pH 6.2, 20 mM sodium ascorbate, 1 mM -ketoglutaric acid, 0.4 mM ammonium iron(II) sulfate, 500 M 3,4- cis -leucocyanidin ( 6 ) and 2.5 M At LDOX, which was incubated at 30 C for 15 min at 1,200 rpm using a 3 mm shaking diameter

Gonda, Y., Matsuda, A., Adachi, K., Ishii, C., Suzuki, M., Osaki, A., Mita, M., Nishizaki, N., Ohtomo, Y., Shimizu, T., Yasui, M., Hamase, K., & Sasabe, J

Serum samples were immediately analyzed, Tempus tubes were stored at 20C, and all other sample types were divided into small aliquots and stored at 80C for later testing

Injections are placed just under the skin in the abdomen, thigh, or upper arm, and patients rotate sites weekly to avoid irritation